What are researchers doing to find a psoriasis cure? Here are a few of the hottest new research areas.
Infections as triggers
We already know that a strep throat infection can bring on one type of psoriasis
(guttate psoriasis). But could other infections be involved? Scientists
are examining the role of many different bacteria and viruses, such as papillomaviruses,
Staphylococcus, and Malassezia furfur, to see whether they could
be triggers for psoriasis. Once we know which infections are triggers, treatments
and screening tests can be developed to help prevent and control psoriasis.
Genetic research
In psoriasis, skin cells in the affected areas grow out of control, leading
to scaly patches. Researchers are identifying the genes that are involved in
uncontrolled skin cell growth. The goal is then to develop treatments that target
these genes and help keep skin cell growth under control.
Fine-tuning the immune system
The immune system plays a complex role in psoriasis. Older treatments targeted
the whole immune system, which can increase the risk of infections. Understanding
which parts of the immune system are involved in psoriasis will help in developing
treatments that target only the problem areas. Biologics are one example of
targeted treatment. They act on the T-cells, which are overactive in psoriasis.
Researchers are also looking for other new targets. One promising target is
the cytokines. Cytokines are the chemical messengers that immune system
cells use to communicate. Targeting the cytokines could produce a fine-tuned
treatment with fewer side effects.
Attacking the supply lines
In order to grow, skin cells need a blood supply. Scientists are working on
treatments that could block new blood vessels from forming in areas affected
by psoriasis. By stopping new blood vessels from forming in these areas, skin
cell growth could be brought under control. This could help treat psoriasis.
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